4-1BB (CD137) is a 39 kD transmembrane protein that is a member of the tumor necrosis factor (TNF) receptor family and is a co-stimulatory molecule that plays a role in T-cell-mediated proliferative response.

Genome Med 12, 4 (Abstract); Lees W, Busse CE, Corcoran M, Ohlin M, Scheepers artery lesion inflammation upon treatment with the CD137 agonistic antibody 2A. acquire expression of CCL4, CCL5 and 4-1BB implicated in cell survival.

The CD137 receptor plays a key role in mediating immune response by promoting T cell proliferation, survival, and memory. Effective agonism of CD137 has the potential to reinvigorate potent antitumor immunity either alone or in combination with other immune-checkpoint therapies. In this study, we describe the discovery and characterization of a unique CD137 agonist, 7A5, a fully human IgG1 Fc TNFRSF9 / 4-1BB / CD137 is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. Jan 10, 2011 Originally discovered as a T cell-activating molecule, 4-1BB (CD137) is now also recognized as an activator of non-T cells, thus imparting a Oct 8, 2020 The Fas-4-1BB chimera fosters adoptive T cell therapy in a powerful and translatable fashion. Jul 10, 2017 The T-cell surface receptor, 4-1BB (CD137), has been of increasing interest to immunologists as a co-stimulatory immune checkpoint molecule Invitrogen Anti-CD137 (4-1BB) Monoclonal (17B5), eBioscience™, Catalog # 16- 1371-85.

Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. 4-1BB (CD137) is another costimulatory receptor expressed on activated T cells (CD4+, CD8+, and NKT), activated NK cells, DCs, eosinophils, and mast cells.

4-1BB (CD137) is another costimulatory receptor expressed on activated T cells (CD4+, CD8+, and NKT), activated NK cells, DCs, eosinophils, and mast cells. 4-1BB is a member of the TNFR superfamily that is inducibly expressed on T cells following stimulation through the TCR complex. 153–155 The ligand of 4-1BB (4-1BBL or CD137L), a member of the TNF family, is expressed on activated

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Signaleringsdomäner från en mängd olika co-stimulatoriska molekyler har framgångsrikt testats, inklusive CD28, CD27, CD134 (OX40) och CD137 (4-1BB).

Growing evidence indicates 4-1BB (CD137) Antibodies for Flow Cytometry CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells.

4-1BB is also expressed on Tregs and DCs. Its ligand 4-1BBL, a member of tumor necrosis factor superfamily, is expressed on activated APCs including DCs, macrophages, and B cells. CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand.
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With the ﬁrst monoclonal antibodies speciﬁc for this surface glycoprotein, these same inves- 4-1BB ligand receptor. CDw137. T-cell antigen 4-1BB homolog. T-cell antigen ILA. CD_antigen: CD137 It is also called 4-1BB or CD137 (1, 2). 4-1BB/CD137/TNFRSF9 is expressed in activated CD4+ and CD8+ T cells, natural killer cells and dendritic cells (2-5).

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CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand.

References and Citations. Nov 8, 2019 The tumor necrosis factor receptor superfamily member 9 (TNFRSF9), also known as CD137 or 4-1BB, is another important immune-modulating CD137 is a member of the tumor necrosis factor (TNF) receptor family and the human homologue of mouse 4-1BB (1). Similar to its mouse counterpart, human Recombinant HEK293 cell line expressing a full length human CD137 (4-1BB) ( NM_001561). The NF-ĸB luciferase reporter construct is stably integrated into Recombinant Monoclonal Antibody.

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4-1BB, also known as CD137 and TNFRSF9, is a transmembrane TNF receptor superfamily member that is expressed as on various populations of activated T cell including CD4+, CD8+, memory CD8+, NKT, and regulatory T cells as well as on myeloid and mast cell progenitors, dendritic cells, mast cells, and bacterially infected osteoblasts. 4-1BB binding by 4-1BB Ligand costimulates T cell

CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting 4-1BB, also known as CD137 and ILA (induced by lymphocyte activation), is a TNF receptor superfamily member and has been designated TNFRSF9.